Objective To explore the effects of clinical thinking and decision-making course for students of Master of Nursing Specialist（MNS）. Methods We selected 50 students of MNS from a nursing college of Hunan province and used SNAPPS method to teach clinical thinking and decision-making courses. Teachers explained and guided students’ learning through cases according to the steps of summarizing,narrowing,analyzing,probing,planning and selecting. The examination scores and evaluation from students were compared between the students recruited in 2017 and in 2018. Results The comprehensive examination scores,autonomous learning ability,inquiry learning ability,communication and summary ability,clinical thinking ability and teaching satisfaction of students in 2018 were significantly higher than those of students in 2017（P<0.05）. Conclusion The course of clinical thinking and decision-making for students with MNS is beneficial to the cultivation of students’ clinical thinking ability,and worth of promotion.