During the epidemic period of COVID-19,a tertiary stomatological hospital has adjusted and optimized the diagnosis and treatment process for oral emergency with spray treatment in order to effectively avoid cross infection between patients and healthcare professionals. The measures mainly included：taking temperature for patients,conducting epidemiological investigation;confirming the necessity of spray treatment,performing three levels of protection,requiring patients rinse their mouth by the povidone-iodine solution for at least 2 minutes,and disinfecting the environment and materials according to the national requirements for COVID-19. During the epidemic,a total of 2 336 oral emergency patients were admitted to our hospital. Of these,111 patients with oral emergency completed spray treatment,and no cross-infection was observed. Patients did not have fever during the follow up after surgery.