Objective To evaluate the effects of a standardized debriefing applied in high fidelity simulation teaching. Methods Fifty-four nursing undergraduates of Grade 2015 were selected and divided into eight groups. All students received 40 class hour high fidelity simulation teaching from March 2018 to January 2019. The standardized debriefing（experience expression，objectives review，actions analysis，summary & reflection）was used. A self-designed questionnaire was used to evaluate the effects of the standardized debriefing. Results The standardized debriefing could make the debriefing closely target the teaching objectives and avoid digressing（100%），promote students’ self-reflection（100%），enable learners to actively participate in the discussion（100%），help the participants to identify their own shortcomings（100%），cultivate clinical reasoning ability（96.3%），promote observers to observe the "patients" carefully（96.3%），and realize the educational concept of student-centered educational learning（96.3%）. Conclusion The standardized debriefing can encourage students to actively participate in debriefing，promote participants to actively reflect on their own performance，and greatly improve the effects of debriefing. Standardized defriefing is worth of reference and promotion.