Objective To evaluate the effects of the curriculum ideological and political education teaching reform applied in the course of Nursing Ethics. Methods The ideological and political elements and the professional knowledge were integrated. Case based learning,class activities（debate,role-play）,mind maps were applied in Nursing Ethics among 101 year 2 undergraduate nursing students. The exam performances were assessed by the combination of formative assessment and summative assessment. The effects of teaching reform were evaluated by the education committee,students and the course group. Results The overall evaluation of teaching reform by the experts of the education committee was good. Students’ overall satisfaction with teaching reform was 92.5%.The organization of case based learning and class activities needed further improvement from the reflection of the instructors. Conclusion The teaching reform enriches the ideological and political content,improves the teaching methods,and implements effective moral infiltration,which is conducive to the improvement of students’ ideological and political quality.