目的 探讨COPD患者生活空间水平变化轨迹潜在类别及其影响因素。 方法 采用前瞻性研究设计，选取2023年1月—2024年2月浙江中医药大学附属第一医院收治的179例COPD患者为调查对象，分别在其出院时（T0）、出院后1个月（T1）、3个月（T2）、6个月（T3）、12个月（T4）通过生活空间评价量表对其进行调查，采用潜类别增长模型识别COPD患者生活空间水平变化轨迹的潜在类别，使用多分类Logistic回归分析其影响因素。 结果 179例COPD患者的生活空间水平变化轨迹可分为3个潜在类别，即“低水平-缓慢改善组”（21.8%）、“中水平-改善组”（55.3%）、“中水平-渐进下降组”（22.9%）。以“中水平-改善组”为参照，COPD病程≤5年者更不易进入“低水平-缓慢改善组”，年龄≤70岁、性格类型为外向、无久坐行为、呼吸困难指数<3级、近1年COPD急性加重频次≤2次者更不易进入“低水平-缓慢改善组”或“中水平-渐进下降组”（P<0.05）。 结论 COPD患者的生活空间水平变化轨迹存在群体异质性，医护人员可基于患者生活空间水平变化轨迹特征及相关可控因素制订并实施针对性干预方案，以提高患者的生活空间水平。

Objective To explore the latent classes of live-space mobility trajectory and their influencing factors in COPD patients. Methods A prospective study was conducted on 179 COPD patients hospitalized at the First Affiliated Hospital of Zhejiang Chinese Medical University from January 2023 to February 2024. Life-space mobility was assessed at discharge（T0） and 1 month（T1），3 months（T2），6 months（T3），and 12 months（T4） post-discharge using the Live-Space Assessment. Latent class growth modeling was utilized to identify trajectory patterns，and multinomial Logistic regression was conducted to analyze influencing factors. Results The trajectory of life-space mobility of 179 COPD patients could be divided into three potential categories，namely the “low level-slow improvement group”（21.8%），the “medium level-improvement group”（55.3%），and the “medium level-progressive decline group”（22.9%）. Compared to “medium level-improvement group”，patients with COPD duration ≤5 years were less likely to fall into “low level-slow improvement group”，while those aged ≤70 years，extroverted personality types，no sedentary behavior，dyspnea index <3，and ≤2 acute exacerbations in the past year were less likely to enter “low level-slow improvement group” or “medium level-progressive decline group”（P<0.05）. Conclusion COPD patients exhibit heterogeneity in live-space mobility trajectories. Healthcare providers can develop targeted interventions based on the characteristics of these trajectories and relevant modifiable factors to improve live-space mobility levels.