目的 构建三级医院心血管科护士置信职业行为（entrustable professional activities，EPAs）指标体系，为评价其岗位胜任力提供科学工具。 方法 采用文献分析、半结构式访谈及德尔菲法，初步建立三级医院心血管科护士EPAs指标、描述说明及基于工作年限的分层预期置信级别；通过对56名护士的EPAs评价，检验指标可行性。 结果对12个省级行政区16所医院的22名心血管护理专家发放了2轮函询问卷，2轮问卷有效回收率均为100%，2轮专家权威系数为0.842、0.856，Kendall协调系数为0.289、0.309（P<0.001）。形成10项EPAs指标（含29条描述说明）及预期置信级别。临床初步应用显示：多数EPAs项目达标率随工作年限增长呈上升趋势，但EPA8（一站式杂交手术整合护理）与EPA10（专业实践发展）的达标率（第5年末分别为59%、53%）相对较低。 结论 构建的三级医院心血管科护士EPAs指标融合了5C能力框架和心血管护理实践要求，包括职业素养、审辨思维、沟通能力、团队合作、创新思维5个能力维度，10项EPAs指标，聚焦29条可观察、可量化的临床任务。该EPAs指标可有效识别能力缺口并促进专业成长，可为三级医院心血管内外科融合发展和急危重症救治背景下心血管科护士岗位胜任力评估和临床教学培训方向提供参考。

Objective To construct an indicator system for entrustable professional activities（EPAs） of nurses in the cardiology department of tertiary hospitals，providing a scientific tool for evaluating their job competency. MethodsUsing literature analysis，semi-structured interviews，and the Delphi method，this study preliminarily established EPAs indicators，descriptive explanations，and expected entrustment levels stratified by working years for nurses in the cardiovascular department of tertiary hospitals. The feasibility of the indicators was verified by EPAs evaluation in 56 nurses. Results Two rounds of questionnaire surveys were distributed to 22 cardiovascular nursing experts from 16 hospitals in 12 provinces. The effective response rates for both rounds were 100%. Expert authority coefficients was 0.842 and 0.856，with Kendall’s W coefficient of concordance being 0.289 and 0.309 respectively（P<0.001）. Ten EPAs indicators（including 29 description items） and expected entrustment levels were established. Preliminary clinical application showed that the achievement rates for most EPAs items increased with working years，but the rates for EPA8（Integrated Nursing for One-stop Hybrid Surgery） and EPA10 （Professional Practice Development） were relatively low（59% and 53% at the end of the fifth year，respectively）. Conclusion The EPAs indicators of cardiovascular nurses in tertiary hospitals constructed in this study integrate the 5C competency framework and cardiovascular nursing practice requirements，including five competency dimensions：professional integrity，critical thinking，communication skills，teamwork，and innovative thinking，with 10 EPAs indicators focusing on 29 observable and quantifiable clinical tasks. These EPAs indicators can effectively identify competency gaps and promote professional growth，providing a reference for the assessment of job competency and the direction of clinical teaching and training for cardiovascular nurses in the context of the integration of cardiovascular internal and surgical departments and the treatment of critical illnesses in tertiary hospitals.