目的 构建多器官功能障碍综合征护理的虚拟仿真实验教学项目并初步应用。 方法 选取产妇肝包膜下破裂出血并发多器官功能障碍综合征的典型案例，构建虚拟仿真实验教学项目，将该实验教学项目应用于天津市某高校2022级77名护理专业本科生急危重症护理学课程多器官功能障碍综合征章节的实验教学。该实验教学项目授课后统计学生在线训练时长、访问次数、实验成绩，比较教学前后学生理论考核及自我评价得分。 结果 学生访问次数为2（1，4）次，在线训练时长为21~155[41（27.5，61.5）] min，实验考核成绩为（75.51±12.45）分。教学后学生理论成绩、自我评价得分均高于教学前，差异具有统计学意义（P<0.001）。 结论 多器官功能障碍综合征护理虚拟仿真实验教学项目具有高效易用的特点，丰富了实验教学资源，可为护理临床实践奠定知识和技能基础。

Objective To construct a virtual simulation experimental teaching program for multiple organ dysfunction syndrome and apply it preliminarily. Methods A research team was formed to select typical cases of postpartum liver subcapsular rupture bleeding complicated with multiple organ dysfunction syndrome to construct the virtual simulation experimental teaching program. The program was applied to the experimental teaching of the multiple organ dysfunction syndrome chapter in the Emergency and Critical Care Nursing course for 77 undergraduate nursing major students in a university in Tianjin in the class of Grade 2022. After the teaching，the duration of online training，number of visits，and experimental scores of the students were analyzed. An online theoretical assessment and self-evaluation were conducted before and after the teaching. Results The number of student visits was 2（1，4） times，the online training duration was 21~155[41（27.5，61.5）] minutes，and the experimental assessment score was（75.51±12.45） points. After teaching，students’ theoretical scores and self-evaluation scores were higher than before，and the difference was statistically significant（P<0.001）. Conclusion The virtual simulation experimental teaching program for multiple organ dysfunction syndrome is high efficient and easy to use. It can enrich the experimental teaching resources，and lay a certain knowledge and skills foundation for nursing clinical practice.