目的 探讨以提升实践应用能力为目标的混合式教学改革在护理本科生统计学方法教学中的效果。 方法 采用随机数字表法选取护理学院2022级5个护理本科班中的2个班级作为试验组和对照组。试验组采用以提升实践应用能力为目标的混合式教学模式进行教学。对照组采用线上自主学习+线下常规讲授法进行教学。授课结束后对两组的统计学方法理论考试成绩、学生对教学方案效果评价进行比较。 结果 试验组统计学方法中的t检验、四格表 χ²检验、单因素方差分析、两独立样本非参数检验、多元线性回归分析、二元Logistic回归分析得分和总成绩得分高于对照组（P<0.05）；资料类型的划分、相关性分析得分比较，两组差异无统计学意义（P<0.05）。试验组教学方案效果评价总分和学习动机与参与度、学习能力与科研素养、教学方案认可度维度得分均高于对照组（P<0.05）。 结论 以提升实践应用能力为目标的混合式教学改革能激发学生的学习热情和参与度，提高了学生的学习能力、任务完成度和对教学方法的认同及统计学方法的知识水平。

Objective To explore the application effect of a blended teaching model aimed at enhancing practical application skills in the teaching of statistical methods for undergraduate nursing students. Methods Two classes from five undergraduate nursing classes of the Nursing College of a university in grade 2022 were classified into the experimental group or control group through the random number table method. The experimental group was carried out a blended teaching model aimed at enhancing practical application skills，while the control group was taught by online self-directed learning combined with traditional offline lectures. After the course，the theoretical examination scores on statistical methods，students’ evaluations of the teaching approach，and the completion status of investigations were compared. Results In the experimental group，the scores were higher than those in the control group，with statistically significant differences（P<0.05） including t-tests，fourfold table chi-square tests，one-way analysis of variance，non-parametric tests for two independent samples，multiple linear regression analysis，and binary logistic regression analysis，as well as the total score. However，no significant differences were found in the classification of data types and correlation analysis scores（P>0.05）. The experimental group also scored higher than the control group in the overall evaluation of the teaching approach，as well as the dimensions of learning motivation and participation，learning ability and research literacy，and recognition of the teaching approach，with statistically significant differences（P<0.05）. Conclusion A blended teaching model aiming at enhancing practical application skills can stimulate students’ enthusiasm and participation，improve their learning ability，task completion rate，recognition of teaching methods，and level of knowledge in statistical methods.