目的 探讨将O-AMAS（Objective教学目标，Activation课堂激活，Multi-learning多元学习，Assessment有效测评，总结Summary）有效教学模型、以案例为基础的学习（Case-Based Learning，CBL）联合应用于基础护理学课程思政教学的效果。 方法 对基础护理学课程思政教学进行设计，主要步骤包括确定课程思政目标及思政元素、设计“课程”与“思政”融合方案、教学实施设计、教学资源建设。对某医学院校2022级344名全日制护理本科生开展基础护理学课程思政教学，通过课程成绩及护理专业学生职业认同问卷、护理本科专业课课程思政教学调查问卷、学生访谈结果，评价课程思政教学效果。 结果 学生课程成绩为（78.92±7.13）分；职业认同条目均分为（3.38±0.61）分；对基础护理学课程思政教学评价的条目均分为（4.53±0.61）分。从对14名学生的访谈结果中主要提炼出认知转变、能力提升、素养塑造3个主题。 结论 O-AMAS有效教学模型联合CBL的基础护理学课程思政教学取得了良好效果，学生对其满意度高。研究可为基础护理学课程改革、建设提供一定的参考。

Objective To explore the effects of integrating the O-AMAS（Objective，Activation，Multi-learning，Assessment，and Summary） Effective Teaching Model with Case-Based Learning（CBL） in ideological and political education within the Fundamentals of Nursing course. Methods A design for ideological and political education in the Fundamentals of Nursing course was formulated，which mainly included determining ideological and political objectives and elements，designing an integration plan for “course” and “ideological and political”，planning teaching implementation，and constructing teaching resources. The ideological and political education was conducted in the Fundamentals of Nursing course for 344 full-time undergraduate nursing students of the 2022 cohort at a medical college. The teaching effects were evaluated through course grades，the results of Professional Identity Questionnaire for Nursing Students，the Questionnaire on Ideological and Political Education in Professional Nursing Courses for Undergraduates，and student interviews. Results The course scores of the 344 students were（78.92±7.13） points；the mean score for the items on professional identity was（3.38±0.61） points；and the mean score for the items on the evaluation of ideological and political education in the Fundamentals of Nursing course was（4.53±0.61） points. Three themes were extracted from the interview with 14 students：transformed cognition；enhanced abilities；cultivated professional qualities. Conclusion The O-AMAS Effective Teaching Model combined with CBL demonstrated positive outcomes in ideological education for Fundamentals of Nursing，with high student satisfaction. This study can provide valuable references for course reform and construction in Fundamentals of Nursing.