目的 设计急性白血病患者护理虚拟仿真实验教学项目，并探讨其应用效果。 方法 立足学生视角，构建包括知识点预习、练习模式、考核模式及实验测评报告4个模块，涉及“安全、沟通、评估、干预、药物/静脉注射管理、效果评价”六大类反应动作的急性白血病患者护理虚拟仿真实验教学项目。将该实验应用于该院2020级和2021级78名护理专业本科生内科护理学课程“白血病”一节的实验教学。教学结束后，统计学生在线训练时长、访问次数、实验成绩等；自行设计调查问卷，邀请学生对急性白血病患者护理虚拟仿真实验系统可用性及教学效果进行评价。 结果 练习模式下，学生访问次数为3（1，5）次，在线训练时长为29~346[53（48，132）] min，学生平均练习成绩为（78.34±16.96）分；考核模式下，学生成绩为（92.28±4.75）分，考试时长为（45.09±5.23） min。84.6%（66/78）的学生对系统总体感到“满意”或“非常满意”，78.2%（61/78）的学生认为系统在易用性上为“容易”或“非常容易”，80.8%（63/78）的学生认为系统在有效性上为“有效”或“非常有效”。75.6%~93.6%的学生对该虚拟仿真实验教学项目起到的各教学效果（提高白血病病情观察能力、锻炼白血病临床护理思维、提高护患沟通能力、激发对白血病的学习兴趣、提高白血病护理能力、培养人文关怀精神、提高项目所涉相关操作技能水平）持认可态度。 结论 急性白血病患者护理虚拟仿真实验教学项目具有可用性，学生对其效果认可度较高，可为急性白血病护理临床实践奠定一定的知识和技能基础。

Objective To design a virtual simulation experimental project for nursing of acute leukemia patients and explore its application effects. Methods From the perspective of students，a virtual simulation experimental project for nursing of acute leukemia patients was constructed，which including four modules：knowledge preview，virtual simulation practice mode，virtual simulation test mode，and experimental evaluation and feedback. The project involved six categories of response actions，namely，safety，communication，assessment，intervention，medication/intravenous management，and effect evaluation. The project was applied to the experimental teaching of leukemia for 78 undergraduate nursing students from the 2020 and 2021 grades at one university. After the teaching，students’ training duration，number of visits，and experimental scores were collected. A self-designed questionnaire was used to invite students to evaluate the system and teaching effects. Results In the practice mode，students visited 3（1，5） times with an online training duration ranging from 29 to 346[53（48，132）] minutes，and the average practice score was（78.34±16.96） points. In the assessment mode，students scored（92.28±4.75） points with an exam duration of （45.09±5.23） minutes. Besides，84.6%（66/78） of students rated “satisfied” or “very satisfied” with the system overall，78.2%（61/78） found the system “easy” or “very easy” to use，and 80.8%（63/78） considered the system “effective” or “very effective” in terms of effectiveness. Between 75.6% and 93.6% of students agreed that the virtual simulation experimental project had several positive teaching effects，including improving the ability to observe leukemia conditions，exercising clinical thinking in leukemia，enhancing nurse-patient communication skills，stimulating interest in learning about leukemia，improving leukemia nursing abilities and strengthening the spirit of humanistic care，and enhancing the level of related operational skills covered in the project. Conclusion The virtual simulation experimental project for nursing of acute leukemia patients is applicable and highly recognized by students for its effectiveness，laying a certain foundation of knowledge and skills for clinical practice in acute leukemia nursing.