目的 构建护理学导论课程知识图谱并进行初步应用。方法 针对护理学导论课程知识体系的整合构建问题，借助知识图谱技术，开展护理学导论课程知识图谱设计与构建；并初步应用于2022级298名护理本科生的教学，从知识点学习人均总时长、已完成内容掌握度、课程满意度、理论成绩进行效果评价。结果 护理学导论课程知识图谱包括认知与理解护理、护理工作思维与方法、护理相关理论与模式3个主题、8个子主题、90个知识主题，涵盖5种知识关系类别。298名学生知识点人均学习总时长20.8 h，84.9%的学生内容掌握度达标，90.3%的学生对课程知识图谱总体评价为非常满意，88.6%的学生对知识图谱课程内容呈现形式评价为非常满意，79.9%的学生对知识图谱学习方法与形式评价为非常满意。2022级学生课程理论考核成绩高于2020级学生（P<0.05）。结论 课程知识图谱是线上线下结合教学模式的强有力支撑，以此开展的线上线下结合式教学有利于打造“以学生为中心”的教学形态，帮助学生构建课程知识体系，优化教学效果。

Objective To develop and preliminarily apply a knowledge graph for the Introduction to Nursing. Methods To address the issue of integrating and constructing the knowledge system of the Introduction to Nursing，with the support of knowledge graph technology，we designed and constructed a knowledge graph for the Introduction to Nursing course. We initially applied it to the teaching of 298 undergraduate nursing students，and evaluated its effectiveness based on the total time per student spent on learning knowledge points，the degree of mastery of completed content，and course satisfaction and theoretical scores. Results The knowledge graph of the Introduction to Nursing course constructed included a total of 90 knowledge topics，covering 5 knowledge learning relationships. The total learning time per capita of 298 students was 20.8 h，84.9% of students met the standard for content mastery，90.3% of students rated the course knowledge graph as very satisfactory overall，88.6% of students rated the presentation of knowledge graph course content as very satisfactory，79.9% of students were very satisfied with the learning methods and forms of knowledge graphs. The theoretical assessment scores of students in 2022 were significantly higher than those of students in 2020（P<0.05）. Conclusion The curriculum knowledge map provides strong support for the online-offline teaching model，as it facilitates the enhancement of the student-centered teaching form，assists students in building a comprehensive curriculum knowledge system，and optimizes the teaching process.