目的 了解成人ICU患者医用粘胶剂相关性皮肤损伤预防与管理的临床现状，明确证据转化过程中的障碍因素并探讨其应对策略。方法 系统化检索相关文献，对纳入文献进行质量评价后提取证据，通过共识会议构建审查指标和确定目标值，开展基线审查，根据审查现状进行障碍因素分析。结果 筛选出转化的证据共29条，制订27条审查指标，仅3条指标的执行率达到目标值。变革层面的主要障碍为缺乏相关护理制度及流程、需调整原有工作程序、冲击护士固有的思维方式；变革接受者层面的主要障碍为护士对工作量增加的抗拒、知识和技能缺乏、家属对医疗负担的担忧；组织环境层面的主要障碍为缺乏激励、支持和反馈机制，现场环境有待改善。结论 成人ICU患者医用粘胶相关性皮肤损伤预防与管理最佳实践的障碍因素多样，应根据这些因素制订以变革、变革接受者、组织环境为中心的改进策略，将变革融入工作流程和管理体系，建立有效的激励机制与反馈机制，促使组织环境改善，推动最佳证据向临床实践转化。

Objective To investigate the current clinical status of the prevention and management of medical adhesion-related skin injury in adult ICU patients，identify the obstacle factors in the process of best evidence transformation，and explore the coping strategies. Methods After systematically searching of relevant literature on this topic，the included literature and summarizing evidence were evaluated so as to establish review criteria and determine target values through consensus meetings. The baseline review was carried out，and the barrier analysis was explored based on the review results. Results A total of 29 evidences were selected for conversion，27 indicators were developed，and only 3 indicators achieved the target value. At the reform level，the main obstacles were the lack of relevant nursing system and process，the need to adjust original working procedures，and the impact on inherent way of thinking of nurses. The main barriers at the change recipient level were nurses’ resistance to increased workload，lack of knowledge and skills，and concern about medical burden of family members. The main obstacles at the organizational environment level included the lack of incentive，support and feedback mechanisms，and the field environment needs to be improved. Conclusion The analysis of obstacles to the process of evidence-based practice are helpful in identifying the resistance to change accurately，formulating improvement strategies centered on change，changing recipients and organizational environment，integrating the change into the work process and management system，and establishing effective incentive and feedback mechanisms to improve organizational environment. Ultimately，the best evidence will be translated into clinical practice.