目的 总结肠造口患者皮肤黏膜分离预防与护理的相关证据，为造口皮肤黏膜分离伤口的护理实践提供循证依据。方法 基于PIPOST模式确定循证问题，在UpToDate、Cochrane Library、乔安娜布里格斯研究所循证卫生保健中心数据库、PubMed、中国知网、万方等数据库及世界造口治疗师协会、美国伤口造口失禁护士协会等专业网站检索与肠造口皮肤黏膜分离预防与护理相关的中英文文献，检索的文献证据类型为专家共识、指南、系统评价和证据总结等，检索时限为建库至2022年11月。经由系统的文献检索、筛选、评价、证据整合，形成肠造口患者皮肤黏膜分离预防与护理的证据。结果 共纳入10篇文献，包括指南4篇、专家共识3篇、系统评价2篇、证据总结1篇。证据内容涉及围术期评估、造口位置标记、皮肤黏膜分离处理、健康教育4方面内容，形成了18条相关证据。结论 本研究针对肠造口患者造口皮肤黏膜分离的预防与护理进行了证据总结，可为临床护理人员进行肠造口皮肤黏膜分离预防与护理提供循证依据，从而提高护理质量。

Objective To summarize the relevant evidence of prevention and nursing on mucocutaneous separation in patients with enterostomy，in order to provide evidence-based basis of mucocutaneous separation for clinical nursing practice. Methods Based on the PIPOST model，relevant expert consensus，guidelines，systematic review，and summary of evidence，etc. were retrieved in UpToDate，Cochrane Library，JBI，PubMed，CNKI，WCET and WOCN，etc. The retrieval time limit was set from establishment of the databases to November，2022. Through systematic literature search，screening，literature evaluation，and evidence integration，a summary of evidence on the prevention and care of skin and mucous membrane separation in patients with enterostomy has been formed. Results A total of ten literatures were included，including four guidelines，three consensuses，two systematic reviews，one evidence summary，18 pieces of relevant evidence were identified，including assessment，colostomy site marking，mucocutaneous separation nursing and health education. Conclusion This study summarized the evidence for the prevention and care of stomal mucocutaneous separation，and provided standardized management and improve nursing quality for clinical medical staffs to prevent and treat the complication of mucocutaneous separation after surgery.