目的 调查ICU护士急性皮肤衰竭护理知信行现状及影响因素，为开展相关教学培训提供依据。方法 2023年1月—3月，便利选取山东省和北京市4所三级甲等医院ICU护士作为研究对象，采用自行编制的ICU护士急性皮肤衰竭护理知信行调查问卷进行调查。结果 回收有效问卷272份，ICU护士急性皮肤衰竭护理知识维度得分（29.09±7.55）分，态度维度得分为（37.65±5.89）分，行为维度得分（34.62±8.77）分。多元回归分析显示，是否为伤口专科护士、是否接受过急性皮肤衰竭培训、是否护理过急性皮肤衰竭患者是ICU护士急性皮肤衰竭护理知信行的影响因素（P<0.05），学历是ICU护士急性皮肤衰竭护理行为的影响因素（P<0.05）。结论 ICU 护士对急性皮肤衰竭护理的态度较为积极，但知识和行为水平有待提高。护理管理者应针对ICU护士的特点，建立和完善急性皮肤衰竭培训体系，加强相关培训，提高其对急性皮肤衰竭的知信行水平，提高ICU患者急性皮肤衰竭护理质量。

Objective To investigate the status quo and influencing factors of ICU nurses’ knowledge and practice of acute skin failure，and to provide evidence for education and training. Methods From January 2023 to March 2023，280 ICU nurses from four tertiary Grade A hospitals in Shandong Province and Beijing were conveniently selected as the research subjects，and a self-designed questionnaire on ICU nurses’ knowledge，belief，and practice in acute skin failure nursing was used to investigated. Results A total of 272 valid questionnaires were collected. The score of knowledge dimension was（29.09±7.55），the score of attitude dimension was（37.65±5.89），and the score of behavior dimension was（34.62±8.77）. Multiple linear regression analysis showed that wound specialist nurses，had received training in acute skin failure and had cared for patients with acute skin failure were independent influencing factors for ICU nurses’ knowledge and behavior of acute skin failure（P<0.05），and the education level was an influencing factor on nursing behavior of ICU nurses with acute skin failure. Conclusion ICU nurses had positive attitude toward acute skin failure，but their knowledge and behavior scores were low. Nursing managers should establish and improve the training system of acute skin failure according to nurse’ characteristics，strengthen relevant training，and improve their knowledge and practice level of acute skin failure，so as to improve the quality of acute skin failure care for ICU patients.