目的 检索、评价并总结肝硬化伴肌少症患者运动干预的最佳证据，为医疗保健人员提供参考。 方法 计算机检索UpToDate、BMJ、JBI、Cochrane Library、Web of Science、PubMed、Embase、中国知网、万方数据、维普、中国生物医学文献服务系统等数据库中关于肝硬化伴肌少症患者运动干预的文献，检索时限为建库至2023年5月2日。 结果 共纳入10篇文献，包括2篇指南、2篇专家共识、6篇系统评价。最终总结出肝硬化伴肌少症患者包括运动前评估、运动方式、运动强度、运动频率与时间、运动监测、质量控制共6个方面21条最佳证据。 结论 本研究总结了肝硬化伴肌少症患者进行运动干预的最佳证据，建议医疗保健人员对患者进行运动前评估，选择个体化的运动方式、强度、频率和时间，动态监测患者的病情进展、肌肉力量、质量、身体机能等相关指标，从而确保运动干预的安全性与有效性，提升患者的活动耐力与生活质量。

Objective To search，evaluate and summarize the best evidence for exercise intervention in patients with liver cirrhosis and sarcopenia，and to provide reference for health care personnel. Methods To retrieve the literature on exercise intervention in patients with cirrhosis and sarcopenia，a computer-based search was undertaken in databases including UpToDate，BMJ，JBI，Cochrane Library，Web of Science，PubMed，Embase，CNKI，Wanfang Data，VIP，CBM and other databases. The search time limit was set from the establishment of the databases to May 2，2023. Results A total of 10 articles were included，including two guidelines，two expert consensus，and six systematic reviews. Finally，21 best evidences in six aspects including pre-exercise evaluation，exercise mode，exercise intensity，exercise frequency and time，exercise monitoring and quality control were summarized for patients with cirrhosis and sarcopenia. Conclusion This study summarized the best evidence for exercise intervention in patients with liver cirrhosis and sarcopenia. It is recommended that health care personnel should evaluate patients before exercise，select individualized exercise methods，intensity，frequency and time，and dynamically monitor the patients’ disease progression，muscle strength，quality，body function and other related indicators to ensure the safety and effectiveness of exercise intervention and improve the patients’ activity endurance as well as quality of life.