目的 探讨基于混合式教学的理实一体化翻转课堂在基础护理学教学中的应用效果。 方法 采用便利抽样的方法，选取2019级护理本科生为对照组，理论课采用基于混合式教学的翻转课堂，实验课采用传统教学；选取2020级护理本科生为试验组，采用基于混合式教学的理实一体化翻转课堂。通过过程性评价成绩、终结性评价成绩、教师观察和学生反馈来评价教学效果。 结果 试验组过程性评价成绩（除线上学习外）、期末实训考核成绩、课程结业成绩均优于对照组（P<0.05）；教师和学生对基于混合式教学的理实一体化翻转课堂教学模式整体评价均良好。 结论 基于混合式教学的理实翻转可促进学生更系统地掌握知识，提升学生学习的积极性和主动性，提高了学生的实训技能和综合能力，对学生职业素养和职业道德的培养也有较好的效果，可以在护理专业课程教学中借鉴和推广。

Objective To explore the effect of the integrated theory and practice with flipped classroom based on blended teaching in Fundamentals of Nursing. Methods Convenience sampling was used and students from one class of grade 2019 were selected as the control group. Flipped classroom based on blended teaching was adopted in theory course，while traditional teaching was adopted in experimental course. The experimental group was recruited from one class of grade 2020，and the integrated theory and practice flipped classroom was adopted. The teaching effect was evaluated by process evaluation，summative evaluation scores of theoretical examination，teachers’ observation and students’ evaluation of the course. Results The scores of process evaluation，final operation assessment and final evaluation in experimental group were better than those in control group（P<0.05）. Teachers and students held good overall evaluation of the teaching model of the integrated theory with practice of flipped classroom. Conclusion The integrated theory and practice with flipped classroom based on blended teaching can assist students to master knowledge more systematically，enhance students’ enthusiasm and initiative in learning，improve students’ practical training skills and comprehensive ability. Besides，such teaching has a good effect on the cultivation of students’ professional quality and professional ethics. The results can be used for reference and promotion in nursing course teaching.