以建构主义和认知负荷理论为指导，基于国际化视野和跨专业合作视角设计健康信息学选修课。以多学科整合内容体系、多元立体化课程运行和过程性评价，赋予课程高阶性、创新性和挑战度。经过3个学期运行，共有147名来自临床医学、护理学、预防医学等21个专业的本科生选修本课程，课程及格率（≥60分）为97%。学生认可本课程能激发学习兴趣，深化对健康信息学前沿的认知，拓展国际视野；跨专业合作学习有助于培养高阶思维。多学科整合内容体系和多元立体式运行取得良好效果，但还需进一步探索如何突破学科边界，同时保留原有学科特征。

Guided by constructivism and cognitive load theory，an international teaching team consisted of teachers with multidisciplinary backgrounds was developed to design and implement Health Informatics Course with the aim of advancing medical students’ interdisciplinary thinking and informatics knowledge. Health Informatics Course is based on multi-disciplinary integrated course curriculum，multi-dimensional curriculum operation，and formative evaluation，all of which make the course high-order，innovative，and challenging. After 3 semesters of implementation，a total of 147 undergraduates from 21 different majors，including medicine，nursing，preventive medicine，medical informatics etc.，took the course. The pass rate（≥60 points） was 97%. Students recognized that the course could stimulate their interests in learning，deepen their understanding of the frontiers of health informatics，and expand their international vision. Interprofessional collaborative learning is helpful to cultivate students’ higher-order thinking. The course has been shown to have promising results，but further exploration is needed to better explore how to break through the boundaries of disciplines while retaining the original discipline characteristics.