目的 调查实习末期护理实习生对外周中心静脉导管（peripherally inserted central catheter，PICC）相关知识掌握状况，并分析其影响因素，为今后对护理实习生进行PICC知识教育和临床技能培训提供依据。 方法 采用方便取样，自行设计问卷，对160名实习结束的护理实习生进行调查。 结果 护理实习生PICC相关知识得分为（64.87± 15.59）分，其中<60分44名（27.5%），60~80分94名（58.8%），>80分22名（13.8%）。 多元线性回归分析显示，学历、实习 PICC相关科室数、 经PICC输液次数、PICC冲管/封管次数 、PICC操作失误次数是实习生PICC相关知识的影响因素（R2=0.063，F=11.605，P<0.001）。 结论 护理实习生PICC相关知识处于中等水平，相关知识掌握不全面。 应加强护理实习生在校期间PICC理论知识及操作技能的培训，提高其将来在临床护理工作中独立处理PICC问题的能力。

Objective To investigate the level and influence factors of peripheral central venous catheter（PICC） related knowledge among nursing students after clinical practice. Methods Totally 160 nursing students after clinical practice were recruited by convenience sampling method. They were investigated using a self-designed questionnaire. Results The average score of PICC related knowledge was（64.87±15.59）. 44（27.5%） students scored lower than 60 points，94（58.8%） and 22（13.8%） students scored ranged from 60 to 80 points and over 80 points，respectively. Multiple linear regression analysis showed that educational level，the number of practice departments involving PICC skills，PICC pathway infusion times，times of washing and sealing catheters，and the number of mistakes in PICC operation were influence factors of PICC related knowledge. Conclusion PICC related knowledge among nursing students after clinical practice is at medium level，and the relevant knowledge is not yet comprehensive. It is suggested to strengthen the training of PICC related knowledge and skills for nursing students，in order to improve their ability to handle problems in PICC nursing in clinical practice and guarantee the safety of nursing care.