ISSN 2097-6054（网络） ISSN 1672-9234（印刷） CN 11-5289/R
主管：中国科学技术协会　主办：中华护理学会
出版：中华护理杂志社
收录：中国科学引文数据库（CSCD）来源期刊
　　　中国期刊全文数据库
　　　中国核心期刊（遴选）数据库
　　　Scopus
中华护理教育

中华护理教育 >

2021 , Vol. 18 >Issue 11: 1032 - 1039

DOI: https://doi.org/10.3761/j.issn.1672-9234.2021.11.014

临床实践

银离子敷料联合负压引流治疗感染性伤口的系统评价

  • 周凌寒 ,
  • 康丽萍 ,
  • 康良琦 ,
  • 卢淑婷 ,
  • 赖英桃 ,
  • 陈雷雷
展开
  • 510405 广州市 广州中医药大学第一临床医学院
周凌寒：女,本科（硕士在读）,护士,E-mail： 657082962@qq.com

收稿日期: 2021-03-11

  网络出版日期: 2021-11-26

收起

Silver ion dressing combined with negative pressure drainage for the treatment of infectious wounds：a systematic review

  • Ling-han ZHOU ,
  • Li-ping KANG ,
  • Liang-qi KANG ,
  • Shu-ting LU ,
  • Ying-tao LAI ,
  • Lei-lei CHEN
Expand

Received date: 2021-03-11

  Online published: 2021-11-26

Fold

摘要

目的 探讨银离子敷料联合负压引流治疗感染性伤口的有效性。方法 检索Cochrane Library、PubMed、Embase、Web of Science、中国生物医学文献服务系统、中国知网、万方数据平台、维普中文期刊服务平台等数据库中关于银离子敷料联合负压引流治疗感染性伤口的随机对照研究,由2名研究人员进行资料提取和文献质量评价,并使用RevMan 5.4软件进行Meta分析。结果 共纳入9篇文献,总样本量为690例,其中试验组采用银离子敷料联合负压引流疗法,对照组采用银离子敷料、负压引流疗法或常规换药中一种方式进行治疗。Meta分析结果：试验组能降低压疮愈合计分量表评分[MD=-1.44,95%CI（-2.49,-0.39）,Z=2.70,P=0.007]、细菌阳性率[OR=0.37,95%CI（0.27, 0.50）,Z=6.16,P<0.001],缩短伤口愈合时间[MD=-6.70,95%CI（-9.00,-4.40）,Z=5.71,P<0.001],提高伤口痊愈率[OR=3.32,95%CI（1.72,6.40）,Z=3.58,P<0.001]。结论 银离子敷料联合负压引流治疗能有效促进感染性伤口的愈合。

关键词： 负压伤口疗法; 伤口感染; Meta分析; 银离子敷料

本文引用格式

周凌寒 , 康丽萍 , 康良琦 , 卢淑婷 , 赖英桃 , 陈雷雷 . 银离子敷料联合负压引流治疗感染性伤口的系统评价[J]. 中华护理教育, 2021 , 18(11) : 1032 -1039 . DOI: 10.3761/j.issn.1672-9234.2021.11.014

Abstract

Objective To investigate the effectiveness of silver ion dressing combined with negative pressure drainage in the treatment of infectious wounds. Methods A comprehensive literature search was conducted in the Cochrane Library,PubMed,Embase,Web of Science,SinoMed,CNKI,Wanfang Data Platform,VIP datebase and other databases for randomized controlled trials of silver ion dressing combined with negative pressure drainage to treat infectious wound. Two researchers conducted data extraction and quality evaluation,and used RevMan 5.4 software for meta-analysis. Results A total of 9 articles were included,with a sample size of 690. Patients in the experimental group were treated with silver ion dressing combined with negative pressure drainage therapy,and patients in the control group were treated with silver ion dressing,negative pressure drainage therapy or conventional dressing change. Meta analysis results showed that the silver ion dressing combined with negative pressure drainage therapy can reduce the Pressure Ulcer Scale for Healing score[MD=-1.44,95%CI（-2.49,-0.39）,Z=2.70,P=0.007],positive rate of bacteria[OR=0.37,95%CI（0.27,0.50）,Z=6.16,P<0.001],wound healing time [MD=-6.70,95%CI（-9.00,-4.40）,Z=5.71,P<0.001],and improve the wound healing rate[OR=3.32,95%CI（1.72,6.40）,Z=3.58,P<0.001]. Conclusion Silver ion dressing combined with negative pressure drainage therapy can effectively promote the healing of infectious wounds.

Key words： Negative-Pressure Wound Therapy; Wound Infection; Meta-Analysis; Silver ion dressing

参考文献

[1] Taati Moghadam M, Khoshbayan A, Chegini Z, et al. Bacteriophages,a new therapeutic solution for inhibiting multidrug-resistant bacteria causing wound infection:lesson from animal models and clinical trials[J]. Drug Des Dev Ther, 2020, 14:1867-1883.
[2] Rahim K, Saleha S, Zhu X, et al. Bacterial contribution in chro-nicity of wounds[J]. Microb Ecol, 2017, 73(3):710-721.
[3] Kucisec-Tepes N. The role of antiseptics and strategy of biofilm removal in chronic wound[J]. Acta Med Croat, 2016, 70(1):33-42.
[4] Kapp S, Miller C, Santamaria N. The quality of life of people who have chronic wounds and who self-treat[J]. J Clin Nurs, 2018, 27(1/2):182-192.
[5] Badia JM, Casey AL, Petrosillo N, et al. Impact of surgical site infection on healthcare costs and patient outcomes:a systematic review in six European countries[J]. J Hosp Infect, 2017, 96(1):1-15.
[6] Lloyd BA, Murray CK, Bradley W, et al. Variation in postinjury antibiotic prophylaxis patterns over five years in a combat zone[J]. Mil Med, 2017, 182(s1):346-352.
[7] Malone M, Bjarnsholt T, McBain AJ, et al. The prevalence of biofilms in chronic wounds:a systematic review and meta-analysis of published data[J]. J Wound Care, 2017, 26(1):20-25.
[8] 蒋琪霞. 创伤性伤口感染处理现况及应对策略[J]. 创伤外科杂志, 2019, 21(6):401-404.
[8] Jiang QX. Current situation and countermeasure of traumatic wound infection management[J]. J Trauma Surg, 2019, 21(6):401-404.
[9] Green S, Higgins JPT. Preparing a cochrane review[M]// Coch-rane handbook for systematic reviews of interventions:Coch-rane book series. Chichester,UK:John Wiley & Sons,Ltd, 2008:11-30.
[10] 吴欣妮, 刘海棠, 叶晓谊, 等. 银离子敷料结合负压引流对胃肠肿瘤患者手术部位感染的预防[J]. 中华医院感染学杂志, 2017, 27(17):3936-3939.
[10] Wu XN, Liu HT, Ye XY, et al. Effect of silver ion dressing combined with vacuum sealing drainage on treatment of gastrointestinal tumor patients with surgical site infections[J]. Chin J Nosocomiol, 2017, 27(17):3936-3939.
[11] 牛妞. 负压结合抗菌敷料用于伤口细菌生物膜感染的干预研究[D]. 南京:南京大学, 2019.
[11] Niu N. Intervention study of negative pressure wound therapy combined with antibacterial dressing for wound bacterial biofilm infection[D]. Nanjing:Nanjing University, 2019.
[12] Sáez-Martín LC, García-Martínez L, Román-Curto C, et al. Ne-gative pressure and nanocrystalline silver dressings for nonhealing ulcer:a randomized pilot study[J]. Wound Repair Regen, 2015, 23(6):948-952.
[13] 周雪燕. 银离子抗菌敷料配合封闭负压引流在压疮感染性伤口中的应用[J]. 首都食品与医药, 2021, 28(4):72-73.
[13] Zhou XY. Application of silver ion antibacterial dressing com-bined with vacuum sealing drainage in the treatment of pressure ulcer infected wound[J]. Capital Food Medicine, 2021, 28(4):72-73.
[14] Hahn HM, Lee IJ, Woo KJ, et al. Silver-impregnated negative-pressure wound therapy for the treatment of lower-extremity open wounds:a prospective randomized clinical study[J]. Adv Ski Wound Care, 2019, 32(8):370-377.
[15] 魏翠艳. 银离子敷料联合负压封闭引流技术治疗糖尿病足伤口感染的效果[J]. 深圳中西医结合杂志, 2020, 30(3):112-113.
[15] Wei CY. The effect of silver ion dressing combined with negative pressure sealing drainage technique in the treatment of diabetic foot wound infection[J]. Shenzhen J Integr Tradit Chin West Med, 2020, 30(3):112-113.
[16] 李翠琼, 胡艳芬, 邓爱平. 银离子辅料联合持续封闭式负压引流治疗糖尿病足溃疡42例护理与疗效观察[J]. 齐鲁护理杂志, 2018, 24(3):13-15.
[16] Li CQ, Hu YF, Deng AP. Nursing and observation on 42 cases of diabetic foot ulcer treated with silver ion excipient combined with continuous vacuum sealing drainage[J]. J Qilu Nurs, 2018, 24(3):13-15.
[17] 蒋琪霞, 王建东, 彭青, 等. 负压伤口治疗结合纳米银敷料处理创伤性慢性伤口的效果比较[J]. 医学研究生学报, 2019, 32(11):1198-1202.
[17] Jiang QX, Wang JD, Peng Q, et al. Comparison of the effect about improved negative pressure wound therapy with filling dressing for treating traumatic wounds[J]. J Med Postgra, 2019, 32(11):1198-1202.
[18] 成沛玉, 杨剑英, 鄢碧玙, 等. 自制负压装置联合纳米银敷料治疗手术切口感染的效果[J]. 中华现代护理杂志, 2018, 24(23):2828-2831.
[18] Cheng PY, Yang JY, Yan BY, et al. Clinical research on self-made negative pressure drainage with nano-silver dressing in surgical incision infection[J]. Chin J Mod Nurs, 2018, 24(23):2828-2831.
[19] Truchetet F, Guibon O, Meaume S. Clinicians’ rationale for using a silver dressing:the French OMAg+E observational study[J]. J Wound Care, 2012, 21(12):620,622-625.
[20] Chang L, Duan W, Chen A, et al. Preparation of polyacrylonitrile-based fibres with chelated Ag ions for antibacterial applications[J]. R Soc Open Sci, 2020, 7(7):200324.
[21] 陈美婉, 吴红梅, 刘长秀, 等. 不同纳米银制剂抑菌作用的实验研究[J]. 中国消毒学杂志, 2009, 26(2):132-134.
[21] Chen MW, Wu HM, Liu CX, et al. Study on the bacteriostatic effect of different dosage forms of silver nanoparticles[J]. Chin J Disinfect, 2009, 26(2):132-134.
[22] Glavan N, Jonjić N. Efficacy of hydrofiber silver dressing in the treatment of posttraumatic skin wounds in children[J]. Wounds, 2015, 27(9):239-243.
[23] Prestes MA, Ribas CA, Ribas Filho JM, et al. Wound healing using ionic silver dressing and nanocrystalline silver dressing in rats[J]. Acta Cir Bras, 2012, 27(11):761-767.
[24] Prasher P, Singh M, Mudila H. Silver nanoparticles as antimicrobial therapeutics:current perspectives and future challenges[J]. 3 Biotech, 2018, 8(10):1-23.
[25] Barrett S. Mepilex Ag:an antimicrobial, absorbent foam dressing with Safetac technology[J]. Br J Nurs, 2009, 18(20):S28,S30-S36.
[26] Nie B, Yue B. Biological effects and clinical application of negative pressure wound therapy:a review[J]. J Wound Care, 2016, 25(11):617-626.
[27] Honnegowda TM, Padmanabha Udupa EG, Rao P, et al. Superficial burn wound healing with intermittent negative pressure wound therapy under limited access and conventional dressings[J]. World J Plast Surg, 2016, 5(3):265-273.
[28] Raj M, Gill SPS, Sheopaltan SK, et al. Evaluation of vacuum assisted closure therapy for soft tissue injury in open musculoskeletal trauma[J]. J Clin Diagn Res, 2016, 10(4):RC05-RC08.
[29] Liu J, Hu F, Tang J, et al. Homemade-device-induced negative pressure promotes wound healing more efficiently than VSD-induced positive pressure by regulating inflammation,proliferation and remodeling[J]. Int J Mol Med, 2017, 39(4):879-888.
[30] Yang G, Lin Q, Wang C, et al. Synjournal and characterization of dextran-capped silver nanoparticles with enhanced antibac-terial activity[J]. J Nanosci Nanotechnol, 2012, 12(5):3766-3774.
[31] Jørgensen B, Price P, Andersen KE, et al. The silver-releasing foam dressing,contreet foam,promotes faster healing of critically colonised venous leg ulcers:a randomised,controlled trial[J]. Int Wound J, 2005, 2(1):64-73.
[32] 毛庆龙. 应用纳米银抗菌敷料治疗烧伤后期残余创面的观察[J]. 中国误诊学杂志, 2009, 9(24):5848-5849.
[32] Mao QL. Observation of the application of nano-silver antibacterial dressing in the treatment of residual burn wounds[J]. Chin J Misdiagn, 2009, 9(24):5848-5849.
Options
文章导航

/

〈 〉