目的 探讨混合式学习在护理学基础课程中的应用效果。 方法 选取28名护理本科生为研究对象,以护理学基础理论课内容开展混合式学习。课前基于MOOC平台开展在线学习、绘制思维导图、在线讨论答疑与测验等;翻转课堂借助某App实现课堂点名、测验、问题解决、案例分析;课后以小组为单位梳理学习资料,实现成果固化与个性化学习。采用学生参与课程的情况、学生MOOC学习成绩、翻转课堂成绩、期末理论考核成绩和学生对课程教学的评价对教学效果进行评价。 结果 50%以上的学生每周投入5 h以上用于MOOC在线学习和绘制思维导图,学生在线学习参与度较高;MOOC成绩为（89.31±16.99）分,学生翻转课堂得分为（92.26±10.15）分,期末理论成绩为（82.57±11.28）分,学生对该教学模式整体评价良好。 结论 在护理学基础课程中开展混合式学习有利于提升学生自主学习能力和综合素质。

Objective To explore the effects of blended learning model applied in the course of Fundamentals of Nursing. Methods The theoretical courses in Fundamentals of Nursing was selected for blended learning model and 28 nursing students took part in the study. Before flipped classroom,students conducted the online learning based on Chinese MOOC,drew the mind maps,discussed online,and finished the online assessments. During the flipped classroom,students finished the class quiz with the help of an App,and conduct problem solution and clinical case analysis. After the class,student organized the learning materials in groups to realize the achievement solidification and conducted personalized learning. Outcomes included students’ participation of the course,academic performance online and in the flipped classroom,final examination results and their evaluation of the new teaching method. Results The students were highly involved in the online learning,with more than 50% of students invested more than 5 hours per week in MOOC online learning and mind mapping and the average online examination result was 89.31±16.99. The average final examination result of all the students was 82.57±11.28,and the flipped classroom academic performance was 92.26±10.15. Students having high comments of the overall evaluation of the blended learning model. Conclusion The innovation of blended learning model for nursing fundamentals can improve students’ independent learning ability and comprehensive quality.